Identification of an Efficient Gene Expression Panel for Glioblastoma Classification

Dendrosomal nanocurcumin and p53 overexpression synergistically trigger apoptosis in glioblastoma cells

Objective(s): Glioblastoma is the most lethal tumor of the central nervous system. Here, we aimed to evaluate the effects of exogenous delivery of p53 and a nanoformulation of curcumin called dendrosomal curcumin (DNC), alone and in combination, on glioblastoma tumor cells. Materials and Methods: MTT assay was exploited to measure the viability of U87-MG cells against DNC treatment. Cells were ...

Feature Selection and Classification of Microarray Gene Expression Data of Ovarian Carcinoma Patients using Weighted Voting Support Vector Machine

We can reach by DNA microarray gene expression to such wealth of information with thousands of variables (genes). Analysis of this information can show genetic reasons of disease and tumor differences. In this study we try to reduce high-dimensional data by statistical method to select valuable genes with high impact as biomarkers and then classify ovarian tumor based on gene expression data of...

The effect of Citrullus colocynthis on the induction of Casp3 and Casp8 gene expression on human Glioblastoma U87 cell line

Introduction: Using in vitro MTT assay and Real-time PCR, the cytotoxicity and cell inhibition mechanism of using Citrullus colocynthis on human glioblastoma U87 cell line was investigated. Methods: The plant extract was extracted using ethanol (70%). To investigate the cytotoxic effects of Citrullus colocynthis extract on U87 cell line, 10 4 cells per well was incubated with different concentr...

The effect of extract of Dunaliella salina L. on the expression of Bax in glioblastoma cancer cell Line

Background & Aims: Plant extracts can change the expression of genes in cancer cells. Till now, no study has been performed on the effect of algae extract. The aim of this research was to study the changes in Bax apoptotic gene expression in glioblastoma cell line and to determine the rate of cell death in cancer cells treated with Dunalilla salina extract. U87 cell line contains glioblas...

Gene Expression Quantification of Toll like Receptors 2, 4 and Co-molecules in Human Glioblastoma Cell Line (U87-MG): Toward a New In vitro Model of Inflammation